https://nova.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Hypothesis and theory: a pathophysiological concept of stroke-induced acute phase response and increased intestinal permeability leading to secondary brain damage https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:39882 Escherichia coli-cell extract antigen (IgA-, IgM-, and IgG-anti-E. coli) were investigated at 1, 2, and 7 days following IS in ten male sheep. We found an increase of both APPs as well as a decrease of all anti-E. coli antibodies within 48 h following IS. This may indicate an early systemic APR and increased IP, and underlines the importance of the increasingly recognized gut-brain axis and of intestinal antigen release for systemic immune responses in acute and subacute stroke stages.]]> Thu 14 Jul 2022 13:17:43 AEST ]]> Ex vivo intestinal sacs to assess mucosal permeability in models of gastrointestinal disease https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:29359 Sat 24 Mar 2018 07:34:17 AEDT ]]> Bioavailability of arsenic, cadmium, lead and mercury as measured by intestinal permeability https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:43435 Papp), with differences in ML retention and complexation amongst the chelants and the gut microbes. The decrease in ML permeability varied amongst the MLs. Chelating agents reduce intestinal absorption of MLs by forming complexes thereby making them less permeable. In the case of gut bacteria, the decrease in the intestinal permeability of MLs may be associated to a direct protection of the intestinal barrier against the MLs or indirect intestinal ML sequestration by the gut bacteria through adsorption on bacterial surface. Thus, both gut microbes and chelating agents can be used to decrease the intestinal permeability of MLs, thereby mitigating their toxicity.]]> Mon 19 Sep 2022 11:35:28 AEST ]]>